Certainly, hiking in the mountains around Vancouver, Canada, or skiing at Whistler when I was younger, I never had any problems. The base was a couple thousand feet above sea level, and that was no problem at all. Taking the lift up another 3000 feet (900m) or so and skiing back down, perhaps I felt it, but as I was not that confident a skier I had other things on my mind, like avoiding the row of trees up ahead.
There are times, though, where changes in altitude can have a serious impact on you.
Specifically, the rate of change is a critical factor that can be life-and-death for you - and also for your projects.
Listen to the podcast or read the full article on Gazza's Corner Blog.